Plastic surgery researchers are always looking for new and better ways of doing things cosmetic.
For instance, surveys show that many people dislike and avoid needles, although needles on surgical syringes have shrunk to virtually nothing and are even coated with special materials so that a puncture is barely felt.
Some plastic surgery researchers have even developed syringes that blow a blast of numbing frigid air just before the needle touches flesh. (Read more about cosmetic surgery ouchless needles.)
Plus, smaller, less painful needles can be used on all types facial fillers.
Other Botox, Dysport and Xeomin (the newest wrinkle fighter) users also say they don’t like needles anywhere near their eyes.
Plus, if unskilled practitioners inject too much Botox, the wrinkle killer can spread under the skin and make an eyelid droop, cause an eyebrow to sag or result in a partially drooping lip that might make you look like you’re pouting. Too much Botox, Dysport, or Xeomin injected into the crows’ feet in an overdose can result in dry eyes. And, bruising at the injection site is always a concern.
Now in stage II clinical trials, a California company is developing a gel that smooths crows’ feet very much like Botox, but without injections. Instead, the substance – now known only as RT001 — is spread on like night cream or sun block…. by a cosmetic plastic surgeon.
But don’t hold your breath just yet; it may be several years before the next, and final, round of clinical trials of topical Botox are finished.
According to the manufacturer, Revance Therapeutics in Mountain View, California, RT001 has been in 11 clinical trials that treated 550 research subjects.
Researchers found the active ingredient, the muscle-paralyzing botulinum toxin type A, does not cross through the skin. But, when combined with another substance – in this case a coating of something known as peptides – the wrinkle fighter penetrates the skin to stop muscle actions resulting in facial wrinkles.
In the latest RT001 tests, about half of patients and researchers saw a huge improvement (from severe to mild) in crows’ feet after a month. About 89 percent saw a modest improvement. Just to make sure they were on the right track, some researchers painted botulinum toxin right on the skin. But nothing happened.
When RT001 goes onto the market – under a more attractive name, of course – it will only be used by doctors and not available for home use.













